PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, an...

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Main Authors MCCAULEY, John A, DWYER, Michael P, LOUGHRAN, H. Marie, HOLLOWAY, M. Katherine, SATYANARAYANA, Tummanapalli, KEERTIKAR, Kartik M, VIJAYASARADHI, Sivalenka, ZHONG, Bin, BENNETT, David J, WADDELL, Sherman Tim, CHU, Xin-Jie, BUNGARD, Christopher J, SHEN, Dong-Ming, WILLIAMS, Peter D, CHANG, Lehua, MORRIELLO, Gregori J, SCHULZ, Jurgen, WISCOUNT, Catherine M, ZORN, Nicolas, JI, Tao, MANIKOWSKI, Jesse J, HU, Bin, SHERER, Edward C
Format Patent
LanguageEnglish
French
German
Published 29.03.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
Bibliography:Application Number: EP20140832049