TARGETING OF CYTOKINE ANTAGONISTS

The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule. In a preferred embodiment, the cytokine antagonist is a modified cytokine which binds to the receptor, but doesn't induce the receptor s...

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Bibliographic Details
Main Authors UZÉ, Gilles, ZABEAU, Lennart, PAUL, Franciane, BORDAT, Yann, GARCIN, Geneviève, TAVERNIER, Jan
Format Patent
LanguageEnglish
French
German
Published 06.11.2019
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule. In a preferred embodiment, the cytokine antagonist is a modified cytokine which binds to the receptor, but doesn't induce the receptor signalling. The invention relates further to a fusion protein according to the invention for use in treatment of cancer and immune- or inflammation-related disorders.
Bibliography:Application Number: EP20140734166