PROCESS FOR PREPARING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREFOR
A process for preparing an amine of the structure which comprises a. treating an aqueous solution of a keto acid of the structure with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase and/or formate dehydrogenase enzyme (PDH/FDH);...
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Main Authors | , , , |
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Format | Patent |
Language | English French German |
Published |
29.06.2016
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Subjects | |
Online Access | Get full text |
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Summary: | A process for preparing an amine of the structure
which comprises
a. treating an aqueous solution of a keto acid of the structure
with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase and/or formate dehydrogenase enzyme (PDH/FDH); and
b. adjusting pH of the reaction mixture with sodium hydroxide to form the desired amine which is substantially free of undesirable excess ammonium ions. |
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Bibliography: | Application Number: EP20150186054 |