CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS

The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercho...

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Main Authors CONNOR, ERIC, MANSKY, PAUL, LEE, ANGELA, KOPPING, JORDON, GOKA, ELIZABETH, SALAMEYEH, FALEH, ZHANG, HONGMIN, QUAKER, GRACE, COPE, MICHAEL JAMES, SHAO, JUN, MU, YONGQI, BERGBREITER, DAVID, LEES, INEZ, MADSEN, DEIDRE, BIYANI, KALPESH, HECKER, SCOTT
Format Patent
LanguageEnglish
French
German
Published 06.04.2016
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Abstract The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndromediarrhea (IBS-D), bile acid malabsorption, and the like.
AbstractList The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndromediarrhea (IBS-D), bile acid malabsorption, and the like.
Author LEES, INEZ
BERGBREITER, DAVID
MADSEN, DEIDRE
SHAO, JUN
KOPPING, JORDON
CONNOR, ERIC
MU, YONGQI
COPE, MICHAEL JAMES
ZHANG, HONGMIN
BIYANI, KALPESH
GOKA, ELIZABETH
HECKER, SCOTT
MANSKY, PAUL
LEE, ANGELA
SALAMEYEH, FALEH
QUAKER, GRACE
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– fullname: GOKA, ELIZABETH
– fullname: SALAMEYEH, FALEH
– fullname: ZHANG, HONGMIN
– fullname: QUAKER, GRACE
– fullname: COPE, MICHAEL JAMES
– fullname: SHAO, JUN
– fullname: MU, YONGQI
– fullname: BERGBREITER, DAVID
– fullname: LEES, INEZ
– fullname: MADSEN, DEIDRE
– fullname: BIYANI, KALPESH
– fullname: HECKER, SCOTT
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DocumentTitleAlternate VERNETZTES POLYVINYLAMIN, POLYALLALAMIN UND POLYETHYLENIMIN ZUR VERWENDUNG ALS GALLENSÄUREKOMPLEXBILDNER
POLYVINYLAMINE, POLYALLYLAMINE ET POLYÉTHYLÈNEIMINE RÉTICULÉES POUR L'UTILISATION COMME SÉQUESTRANTS DE L'ACIDE BILIAIRE
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Snippet The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile...
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SubjectTerms CHEMISTRY
COMPOSITIONS BASED THEREON
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
THEIR PREPARATION OR CHEMICAL WORKING-UP
Title CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS
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