CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS

The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercho...

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Main Authors CONNOR, ERIC, MANSKY, PAUL, LEE, ANGELA, KOPPING, JORDON, GOKA, ELIZABETH, SALAMEYEH, FALEH, ZHANG, HONGMIN, QUAKER, GRACE, COPE, MICHAEL JAMES, SHAO, JUN, MU, YONGQI, BERGBREITER, DAVID, LEES, INEZ, MADSEN, DEIDRE, BIYANI, KALPESH, HECKER, SCOTT
Format Patent
LanguageEnglish
French
German
Published 06.04.2016
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndromediarrhea (IBS-D), bile acid malabsorption, and the like.
Bibliography:Application Number: EP20150180706