CHEMICAL ENTITIES

Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further pr...

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Main Authors BLANCO APARICIO, Carmen, MURGA COSTA, Matilde, PASTOR FERNÁNDEZ, Joaquín, VARELA BUSTO, Carmen, TOLEDO LÁZARO, Luis Ignacio, CEBRIÁN MUÑOZ, David Alvaro, LOPEZ CONTRERAS, Andrés Joaquín, NIETO SOLER, María, RICO FERREIRA, María del Rosario, RODRÍGUEZ ARÍSTEGUÍ, Sonsoles, RENNER, Oliver, FERNÁNDEZ-CAPETILLO RUIZ, Oscar, MARTÍNEZ GONZÁLEZ, Sonia
Format Patent
LanguageEnglish
French
German
Published 28.02.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are chemical entities selected from compounds of formula (I), wherein R1, R2 and m have meanings given in the description, and pharmaceutically acceptable salts, solvates and stereoisomers thereof, which are inhibitors of ATR and are potentially useful in the treatment of cancer. Further provided are pharmaceutical compositions of the chemical entities, combination products containing the chemical entities, the use of the compositions as therapeutic agents, and methods of treatment using these compositions.
Bibliography:Application Number: EP20140716910