TETRACYCLIC BROMODOMAIN INHIBITORS

The present invention provides for compounds of formula (I)wherein R, R, R, Y, Y, Y, A, A, A, and Ahave any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory disease...

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Main Authors DAI, Yujia, WANG, Le, SHEPPARD, George S, MANTEI, Robert A, PRATT, John, HOLMS, James H, DIETRICH, Justin D, LIU, Dachun, MARJANOVIC, Jasmina, HASVOLD, Lisa A, BOGDAN, Andrew, FIDANZE, Steven D, MCDANIEL, Keith F
Format Patent
LanguageEnglish
French
German
Published 17.04.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides for compounds of formula (I)wherein R, R, R, Y, Y, Y, A, A, A, and Ahave any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula (I).
Bibliography:Application Number: EP20140762617