COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising...

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Bibliographic Details
Main Authors DAI, XING, GRESHOCK, THOMAS, STEVENSON, HEATHER, LIU, HONG, SANDERS, JOHN, MILLER, MICHAEL, MCCAULEY, JOHN, A, KERN, JONATHAN, HARRIS, JOEL, M, BASU, KALLOL, SCOTT, JACK, DEMONG, DUANE, STAMFORD, ANDREW, W, POIRIER, MARC, NEUSTADT, BERNARD
Format Patent
LanguageEnglish
French
German
Published 31.08.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
Bibliography:Application Number: EP20140760677