TAU AGGREGATION INHIBITOR

Provided is a tau aggregation inhibitor which can sufficiently inhibit a tau protein from aggregating in cells. The inhibitor includes a 4-substituted catechol structure compound, having, at position 4 of its catechol ring, an electron-donating substituent R other than a hydrocarbon group, or a salt...

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Main Authors OE, YOHEI, OTA, TETSUO, TAKASHIMA, AKIHIKO, INOUE, YOSHIKAZU, MIYASAKA, TOMOHIRO, SUGIMOTO, HACHIRO, TOKIZANE, RIE, IHARA, YASUO, SOEDA, YOSHIYUKI, SHINZAKI, YUKI
Format Patent
LanguageEnglish
French
German
Published 28.09.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided is a tau aggregation inhibitor which can sufficiently inhibit a tau protein from aggregating in cells. The inhibitor includes a 4-substituted catechol structure compound, having, at position 4 of its catechol ring, an electron-donating substituent R other than a hydrocarbon group, or a salt thereof The 4-substituted catechol structure compound is preferably 4-aminocatechol or 1,2,4-benzenetriol. Examples of tauopathies to which this inhibitor is applicable include AD, Down's syndrome, frontotemporal dementia, cotricobasal degeneration (CBD) and progressive supranuclear palsy (PSP).
Bibliography:Application Number: EP20140779014