ANTIDIABETIC BICYCLIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the prese...

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Main Authors BROCKUNIER, LINDA L, HAGMANN, WILLIAM K, XIAO, DONG, DEMONG, DUANE E, MARCANTONIO, KAREN M, CHEN, HELEN, MILLER, MICHAEL, PIO, BARBARA, GUO, YAN, CHOBANIAN, HARRY R, CLEMENTS, MATTHEW J, CRESPO, ALEJANDRO, PLUMMER, CHRISTOPHER W
Format Patent
LanguageEnglish
French
German
Published 10.08.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Bibliography:Application Number: EP20140754282