POLYPEPTIDE AND IMAGING METHOD

A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3); where Xaa 1 represents an aspartic acid in which a -Y-X' group binds to an ±-amino group, X' includes a chelating site and a radioactive metal...

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Bibliographic Details
Main Authors KIMURA, Hiroyuki, KON, Asami, INAGAKI, Nobuya, TOYODA, Kentaro, MATSUDA, Hirokazu, SAJI, Hideo, IOROI, Mikako
Format Patent
LanguageEnglish
French
German
Published 04.09.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NANOTECHNOLOGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
TESTING
TRANSPORTING
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Summary:A peptide that can be used as an imaging probe for GLP-1R is provided. In an embodiment, a polypeptide is represented by the following formula (3); where Xaa 1 represents an aspartic acid in which a -Y-X' group binds to an ±-amino group, X' includes a chelating site and a radioactive metal nuclide chelated by the chelating site, the chelating site being diethylenetriaminepentaacetic dianhydride (DTPA) or 1,4,7-triazacyclononnane-N,N',N"-triacetic acid (NOTA), and Y represents a linker including a group selected from the group consisting of -CH 2 -(C 6 H 4 )-, -NH-C(=S)-, -NH-(CH 2 ) 5 -C(=0)-, and a combination thereof.
Bibliography:Application Number: EP20130858604