Method of increasing bone toughness and stiffness and reducing fractures

• Main Authors: HOCK, JANET M, DERE, WILLARD H, GAICH, GREGORY A
• Format: Patent
• Language: English; French; German
• Published: 19.08.2015
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROSTHESES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TREATMENT OR PROTECTION OF EYES OR EARS

The invention relates to a method for increasing the toughness and/or stiffness of bone in a man, in particular for reducing the likelihood and/or severity of bone fracture by administering parathyroid hormone hPTH(1-34) by subcutaneous injection at less than 1 µg/kg/day. The method can be employed to increase toughness or stiffness of bone at a site of a potential or actual trauma, such as the hip or spine of a person at risk of or suffering osteoporosis. The method of the invention can reduce the incidence of vertebral fracture, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, and/or reduce the incidence of non-vertebral fracture.