PROTECTED SUCCINATES FOR ENHANCING MITOCHONDRIAL ATP-PRODUCTION

Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optiona...

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Main Authors FLIRI, Hans Georg, ELMÉR, Mats Eskil, HANSSON, Magnus Joakim, SJÖVALL, Karl Fredrik Lennart, SCOWEN, David Arthur, FORD, Rhonan Lee, EHINGER, Karl Henrik Johannes, BATCHELLER, Derek Gregory
Format Patent
LanguageEnglish
French
German
Published 06.12.2017
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optionally substituted alkyl group or a group of formula (II) and R2 is independently a group according to formula (II) where formula (II) is as defined 10 herein.
Bibliography:Application Number: EP20130774487