COOLING SYSTEMS AND METHODS FOR CRYO SUPER-RESOLUTION FLUORESCENCE LIGHT MICROSCOPY AND OTHER APPLICATIONS

New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are...

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Bibliographic Details
Main Authors NAHMANI, Marc, INGERSOLL, Charles, G, TURRIGIANO, Gina, DEROSIER, David, J
Format Patent
LanguageEnglish
French
German
Published 06.07.2022
Subjects
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
OPTICS
PHYSICS
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Summary:New systems and methods are described for maintaining a desired steady state temperature differential between two objects that may otherwise undergo heat transfer to restore thermal steady state. In one application, a cooling microscope assembly and its use with conventional optical microscopes are described for achieving super-resolution imaging. The assembly allows for the high resolution imaging of samples at cryogenic temperatures while maintaining the temperature of the objective lens above freezing by employing circulation systems and a coupling fluid between the sample and objective lens.
Bibliography:Application Number: EP20130837090