Improved methods for fermentative production of docosahexaenoic acid

The invention comprises a process of producing polyunsaturated fatty acids from Thraustochytriales at high availability of oxygen by submerged fermentation in a batch, semi-continuous or continuous mode. Batch fermentation of more than 200g/L and up to 450 g/L of dextrose added right in the beginnin...

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Main Authors GANESAN, ELLAPPAN, RATNAM, RAKESH, PETER, VINEETHA, AURORA, SUNDEEP, TALLURI, SURENDRA
Format Patent
LanguageEnglish
French
German
Published 17.06.2015
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Summary:The invention comprises a process of producing polyunsaturated fatty acids from Thraustochytriales at high availability of oxygen by submerged fermentation in a batch, semi-continuous or continuous mode. Batch fermentation of more than 200g/L and up to 450 g/L of dextrose added right in the beginning of fermentation was achieved with productivity of DHA achieved for higher than 10g/Liter. The process comprises maintaining at least 20% to 30% dissolved oxygen and sometimes up to around 50% or more.
Bibliography:Application Number: EP20150150341