IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

• Main Authors: CHOVATIA, Praful Tulshi, RICHARDSON, Anthony John, SELBY, Matthew Duncan, SHAW, Michael Alan, HEIFETZ, Alexander, HUTCHINGS, Martin Clive, PORTER, John Robert, BENTLEY, Jonathan Mark, BROOKINGS, Daniel Christopher, LECOMTE, Fabien Claude, RICHARDSON, Sarah Emily, ZHU, Zhaoning, QUINCEY, Joanna Rachel, KROEPLIEN, Boris, BROWN, Julien Alistair, JOHNSON, James Andrew, LOWE, Martin Alexander, FOLEY, Anne Marie, JACKSON, Victoria Elizabeth, HORSLEY, Helen Tracey, REED, Laura Claire, MADDEN, James, GALLIMORE, Ellen Olivia, CAIN, Thomas Paul, GLEAVE, Laura Jane, LEIGH, Deborah, JOHNSTONE, Craig, REUBERSON, James Thomas
• Format: Patent
• Language: English; French; German
• Published: 29.08.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.