PROCESS FOR PREPARATION OF MONTELUKAST SODIUM

Disclosed is a process for the preparation of montelukast sodium. The process comprises a) reacting 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol with methane sulfonyl chloride and coupling the resultant mesylate compound with 1-(mercaptomethyl)cycloprop...

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Main Authors INDUKURI, VENKATA, SUNIL, KUMAR, CHAVA, SATYANARAYANA, SIMHADRI, SRINIVAS, MOHAMMAD, YASEEN, GORANTLA, SEETA, RAMANJANEYULU
Format Patent
LanguageEnglish
French
German
Published 10.02.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a process for the preparation of montelukast sodium. The process comprises a) reacting 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol with methane sulfonyl chloride and coupling the resultant mesylate compound with 1-(mercaptomethyl)cyclopropane acetic acid in presence of a base and free alkali source followed by saltification with an amine in a single step reaction and b) converting the montelukast amine salt to montelukast sodium salt.
Bibliography:Application Number: EP20130809176