THIAZOLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS

• Main Authors: ADURKAR, SHRIDHAR, KESHAV, RAJE, FIROJ, AFTAB, KAMBOJ, RAJENDER, KUMAR, SINHA, NEELIMA, HAJARE, ANIL, KASHIRAM, TILEKAR, AJAY, RAMCHANDRA, LAIRIKYENGBAM, BIKRAMJIT, SINGH, PALLE, VENKATA P, KARCHE, NAVNATH, POPAT, THUBE, BABAN, RUPAJI
• Format: Patent
• Language: English; French; German
• Published: 14.01.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed is a compound of formula (I) wherein Y, Ring D, m and R1-R4 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the α7 subtype, in a subject in need thereof, as well as pharmaceutically acceptable salts, polymorphs, solvates, and isomers thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.