SYNTHESIS OF RALTEGRAVIR

The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2-methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).

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Bibliographic Details
Main Authors SONAWANE, SWAPNIL PANDITRAO, MAIKAP, GOLAKCHANDRA SUDARSHAN, MEHTA, SAMIT SATISH, SHINDE, SHIVNATH BHAUPATIL, PATIL, PANKAJ SHALIKRAO, GURJAR, MUKUND KESHAV, PATIL, GULABRAO DAGADU
Format Patent
LanguageEnglish
French
German
Published 12.08.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a novel synthetic route for the preparation of raltegravir and pharmaceutically acceptable salts, starting from 2-amino-2-methylpropanenitrile and oxadiazole carbonyl chloride, through the formation of a pyrimidinone intermediate of formula (V).
Bibliography:Application Number: EP20120862643