POLYMYXIN DERIVATIVES
Provided are compounds, the use of the said compounds in treatment, for example treatment of microbial infections, particularly by Gram negative bacteria. The compounds are polymyxin-based and are represented by the formula (I): and pharmaceutically acceptable salts thereof, where X is -NHC(O)-, -C(...
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Main Authors | , , , , |
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Format | Patent |
Language | English French German |
Published |
24.09.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Provided are compounds, the use of the said compounds in treatment, for example treatment of microbial infections, particularly by Gram negative bacteria. The compounds are polymyxin-based and are represented by the formula (I): and pharmaceutically acceptable salts thereof, where X is -NHC(O)-, -C(O)-, -OC(O)-, -CH2- or -SO2-; R5 represents C0-12 alkyl(C4-6 heterocyclyl), or C2-12 alkyl or C0-12 alkyl(C3-8 cycloalkylyl). and the alkyl or cycloalkylyl bears one, two or three hydroxyl groups, or a -NR6R7 group, or one -NR6R7 group and one or two hydroxyl groups; and R1 to R4 and R6 to R8 are as defined in the description. |
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Bibliography: | Application Number: EP20120797961 |