TRIAZOLOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprisin...

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Main Authors COOKE, ANDREW, LONDON, CLARE, RATCLIFFE, PAUL, CAI, JAIQIQANG, TAYLOR, JERRY ANDREW, XIONG, YUSHENG, CARSWELL, EMMA, SAMANTA, SWAPAN KUMAR, BENNETT, D. JONATHAN, HOYT, SCOTT, B, MACLEAN, JOHN, KULKARNI, BHEEMASHANKAR, A
Format Patent
LanguageEnglish
French
German
Published 30.07.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
Bibliography:Application Number: EP20120833774