NOVEL MACROCYCLES AS FACTOR XIA INHIBITORS

or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising t...

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Bibliographic Details
Main Authors FANG, TIANAN, GILLIGAN, PAUL J, CORTE, JAMES R, EWING, WILLIAM R, PINTO, DONALD J, SMITH II, LEON M, WANG, YUFENG, YANG, WU
Format Patent
LanguageEnglish
French
German
Published 11.06.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Bibliography:Application Number: EP20120762427