QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS

Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

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Bibliographic Details
Main Authors DEMEESE, JASON, KINTZ, SAMUEL, CHICARELLI, MARK, JOSEPH, GAZZARD, LEWIS, MOHR, PETER J, SIEDEM, CHRISTOPHER, S, SCHWARZ, JACOB, KAUS, ROBERT J, GARREY, RUSTAM, FERDINAND, GAUDINO, JOHN, BLAKE, JAMES, F, CHEN, HUIFEN, WALLACE, ELI, M, MORENO, DAVID, A
Format Patent
LanguageEnglish
French
German
Published 11.06.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Bibliography:Application Number: EP20120769775