PROCESS FOR PREPARING PRASUGREL

The present invention is directed to an improved process for preparing, prasugrel and maleate salt of Prasugrel and, optionally other pharmaceutically acceptable salts from, prasugrel and said maleate salt, in high yields and purity, which can be used at industrial scale. The process of the present...

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Main Authors NAVARRO MUÑOZ, ISABEL, HEMANT JERE, DEEPAK, PURUSHOTTAM JOSHI, ANIL, DALMASES BARJOAN, PERE, RAGHUNATH BENDRE, SAMIR, HUGUET CLOTET, JUAN, NEWADKAR, RAVINDRANATH VISHNU
Format Patent
LanguageEnglish
French
German
Published 04.06.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention is directed to an improved process for preparing, prasugrel and maleate salt of Prasugrel and, optionally other pharmaceutically acceptable salts from, prasugrel and said maleate salt, in high yields and purity, which can be used at industrial scale. The process of the present invention comprises the steps of bromination, condensation, acetylating and optionally converting into maleate salt and, if desired, conversion into another pharmaceutically acceptable salt from it. The present process is advantageous in terms of productivity, efficacy, purity and also prevents the use of toxic substances.
Bibliography:Application Number: EP20120740371