COMBINATION OF PANOBINOSTAT AND RUXOLITINIB IN THE TREATMENT OF CANCER SUCH AS A MYELOPROLIFERATIVE NEOPLASM

The invention relates to a combination which comprises: (a) Compound A ((R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile) of Formula (A): or a pharmaceutically acceptable salt thereof; and (b) Compound B (N-hydroxy-3-[4-[[[2-(2-methy-1H-indol-3-yl)-ethyl]-amino...

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Bibliographic Details
Main Authors BAFFERT, FABIENNE, GADBAW, BRIAN, RADIMERSKI, THOMAS
Format Patent
LanguageEnglish
French
German
Published 25.05.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to a combination which comprises: (a) Compound A ((R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile) of Formula (A): or a pharmaceutically acceptable salt thereof; and (b) Compound B (N-hydroxy-3-[4-[[[2-(2-methy-1H-indol-3-yl)-ethyl]-amino]methyl]phenyl]-2E-2-propenamide) of Formula (B): or a pharmaceutically acceptable salt thereof; for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferative diseases. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating proliferative diseases, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.
Bibliography:Application Number: EP20120730099