PRO-COAGULANT COMPOUNDS AND METHODS OF USE THEREOF

The present invention provides pro-coagulant compounds (e.g., pro-coagulant peptides or peptide derivatives) and methods of using and making those compounds. The present disclosure further provides conjugates between a pro-coagulant compound of the present disclosure (e.g., pro-coagulant peptide or...

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Bibliographic Details
Main Authors MEZO, Adam R, TOBY, Garabet G, THORN, Karina
Format Patent
LanguageEnglish
French
German
Published 19.12.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides pro-coagulant compounds (e.g., pro-coagulant peptides or peptide derivatives) and methods of using and making those compounds. The present disclosure further provides conjugates between a pro-coagulant compound of the present disclosure (e.g., pro-coagulant peptide or peptide derivative) and a polypeptide selected from FIX, FVIIa, FVIII, and platelet targeting moieties (e.g., PDG-13), wherein the compound is linked to the polypeptide optionally via a linker. The compounds and conjugates of the present disclosure are useful for the treatment of coagulation disorders, such as hemophilia A and hemophilia B. The present disclosure further provides methods of using and making the conjugates.
Bibliography:Application Number: EP20120797036