ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to tricyclic triazole analogs of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the c...

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Main Authors PETRILLI, WHITNEY LANE, LONDON, CLARE, HENDERSON, TIMOTHY, J, HEIM, RALF, YIN, LINA, TAYLOR, JERRY ANDREW, BEY; EMMANUEL, HOYT, SCOTT, B, ALI, AMJAD, HARTMANN, ROLF, SAXENA, ROHIT, LO, MICHAEL, XIONG, YUSHENG, HU, QINGZHONG, SAMANTA, SWAPAN KUMAR, KULKARNI, BHEEMASHANKAR, A
Format Patent
LanguageEnglish
French
German
Published 05.03.2014
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
FISHING
FORESTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:This invention relates to tricyclic triazole analogs of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.
Bibliography:Application Number: EP20120776492