CYCLIC PEPTIDE FROM NONOMURAEA SP., PROCESS FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MYCOBACTERIA RELATED DISEASE COMPRISING THE SAME

The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present i...

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Main Authors GAO, WEI, FRANZBLAU, SCOTT, LANKIN, DAVID, LEE, SANG WOOK, SUH, JOO WON, KIM, JONG WOO, PARK, SANG JIN, LEE, JI EAN, JAKI, BIRGIT, RODRIGUEZ BRASCO, MARIA FLORENCIA, YOON, TAE MI, CHOI, JONG KEUN, LEE, IN AE, NAPOLITANO, JOSE, PAULI, GUIDO, MCALPINE, JAMES, FRIESEN, BRENT, KIM, JIN YONG, JIN, YING YU, CHO, SANGHYUN
Format Patent
LanguageEnglish
French
German
Published 13.04.2016
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
Bibliography:Application Number: EP20120774572