AMINOPYRIMIDINE KINASE INHIBITORS

Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGF pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses...

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Bibliographic Details
Main Authors BALDINO, CARMEN, M, DUMAS, STEPHANE, A, FLANDERS, YVONNE, L, CASERTA, JUSTIN, L, LEE, CHEE-SENG
Format Patent
LanguageEnglish
French
German
Published 12.11.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGF pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim-1, Pim-2, Pim-3, the TGF pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.
Bibliography:Application Number: EP20120774599