PHARMACEUTICAL COMPOSITION CONTAINING BLOCK COPOLYMER COMPRISING BORONIC ACID COMPOUND

• Main Authors: KATO, Yasuki, HARADA, Mitsunori, TANAKA, Ryosuke, KOBAYASHI, Katsutoshi, SAITO, Hiroyuki
• Format: Patent
• Language: English; French; German
• Published: 31.10.2018
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The present invention provides a pharmaceutical composition. The pharmaceutical composition includes a block copolymer includng: a hydrophilic segment; a hydrophobic segment; and a boronic acid compound bonded to a side chain of the hydrophobic segment via a linker moiety including a heterocyclic structure, wherein: a cyclic skeleton of the heterocyclic structure has a boron atom derived from the boronic acid compound, atoms X's bonded to the boron atom and each selected from an oxygen atom and a nitrogen atom, and carbon atoms bonded to the atoms X's; and the block copolymer further comprises an organic group bonded to the carbon atoms, the organic group containing an aromatic group or cyclic alkyl group as a structure for protecting a boronic acid ester bond and/or a boron amide bond resulting from bonding between the boron atom and the atoms X's.