CROSS-REACTIVE STAPHYLOCOCCUS AUREUS ANTIBODY

The subject relates to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the bi-component toxins of Staphylococcus aureus, its medical and diagnostic use, method of producing the antibody, including an isolated nucleot...

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Main Authors PRINZ, BIANKA DOMINIQUE, ROUHA, HARALD, NAGY, GÁBOR, BATTLES, MICHAEL BENJAMIN, NAGY, ESZTER, TEUBENBACHER, ASTRID, DOLEZILKOVA, IVANA, JAEGERHOFER, MICHAELA, MIRKINA, IRINA, BADARAU, ADRIANA, VISRAM, ZEHRA, STULIK, LUKAS, MAGYARICS, ZOLTÁN, ZERBS, MANUEL
Format Patent
LanguageEnglish
French
German
Published 03.06.2015
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The subject relates to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the bi-component toxins of Staphylococcus aureus, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated conformational epitope recognized by a specific cross-neutralizing antibody.
Bibliography:Application Number: EP20130728122