A NEW METHOD FOR THE SYNTHESIS OF RASAGILINE

We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity under very mild conditions with a wide range of reaction condit...

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Bibliographic Details
Main Authors SAHIN, YASEMIN, KOYUNCU, HASAN, GULCAN, H., OZAN, REIS, OEMER, ESIRINGU, ILKER
Format Patent
LanguageEnglish
French
German
Published 20.11.2013
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity under very mild conditions with a wide range of reaction conditions and reagent selection. Considering the ease, purity and high yields of introducing and removal of the trifluoroacetyl group, this approach is a highly practical and economical way for the synthesis of rasagiline or its pharmaceutically acceptable salts.
Bibliography:Application Number: EP20110712351