TNF FAMILY LIGAND VARIANTS

The present invention relates to variants of TNF family ligands which have been mutated at the ligand trimerisation interface so that they are not capable of assembling into trimers, and either assemble into dimers or remain as monomers. Such ligands bind to the TNF receptor but are unable to activa...

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Main Authors QUAX, WILHELMUS, JOHANNES, TUR, VICENTE, R, VAN DER SLOOT, ALBERT, MARTINUS, COOL, ROBBERT, H, ASSEN, AART, H., G., VAN, SERRANO, LUIS
Format Patent
LanguageEnglish
French
German
Published 30.10.2013
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to variants of TNF family ligands which have been mutated at the ligand trimerisation interface so that they are not capable of assembling into trimers, and either assemble into dimers or remain as monomers. Such ligands bind to the TNF receptor but are unable to activate it, effectively functioning as competitive inhibitors. The invention also relates to nucleic acids encoding the variants of TNF family ligands, vectors and host cells comprising the nucleic acid and methods for the treatment of diseases associated with aberrant signalling through a TNF receptor.
Bibliography:Application Number: EP20110813430