CYCLIC AMINE SUBSTITUTED OXAZOLIDINONES AS CETP INHIBITORS

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substituted pheny...

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Main Authors LU, Zhijian, CHEN, Yi-Heng, DONG, Guizhen, VACHAL, Petr, KALLASHI, Florida, ONDEYKA, Debra, L, SUN, Wanying, SWEIS, Ramzi, ZHAO, Kake, SMITH, Cameron, HUNT, Julianne, QIAN, Xiaoxia, LI, Hong, THOMPSON, Christopher, F, SINCLAIR, Peter, ADAMSON, Samantha, E
Format Patent
LanguageEnglish
French
German
Published 15.03.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substituted phenyl group or indanyl group. Formula (I).
Bibliography:Application Number: EP20110836937