N-CARBOXYALKYL AURISTATINS AND THE USE THEREOF

The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of d...

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Main Authors STELTE-LUDWIG, BEATRIX, GOLFIER, SVEN, KRENZ, URSULA, SCHUHMACHER, JOACHIM, GNOTH, MARK, JEAN, EL SHEIKH, SHERIF, LERCHEN, HANS-GEORG
Format Patent
LanguageEnglish
French
German
Published 26.08.2015
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.
Bibliography:Application Number: EP20110760500