Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors

• Main Authors: ITOH, NAOHIRO, SUZUKI, SHINJI, YASUI, KEN, KOBAYASHI, NAOTAKE, YUKIMASA, AKIRA, KANDA, YASUHIKO, UEDA, KAZUO, SAKAGUCHI, GAKU, KORIYAMA, YUJI, HORI, AKIHIRO, KATO, AKIRA, HARAGUCHI, HIDEKAZU
• Format: Patent
• Language: English; French; German
• Published: 30.03.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl...