Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl...

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Main Authors ITOH, NAOHIRO, SUZUKI, SHINJI, YASUI, KEN, KOBAYASHI, NAOTAKE, YUKIMASA, AKIRA, KANDA, YASUHIKO, UEDA, KAZUO, SAKAGUCHI, GAKU, KORIYAMA, YUJI, HORI, AKIHIRO, KATO, AKIRA, HARAGUCHI, HIDEKAZU
Format Patent
LanguageEnglish
French
German
Published 30.03.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl; R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R 5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
Bibliography:Application Number: EP20130150550