VACCINE COMPOSITIONS BASED ON STICHOLYSIN ENCAPSULATED IN LIPOSOMES

The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoyl...

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Main Authors MESA PARDILLO, CIRCE, ALVAREZ VALCARCEL, CARLOS MANUEL, PAZOS SANTOS, ISABEL FABIOLA, TEJUCA MARTINEZ, MAYRA, VALLE GARAY, AISEL, FERNANDEZ MOLINA, LUIS ENRIQUE, CANET SANTOS, LIEM, LANIO RUIZ, MARIA ELIANA, LABORDE QUINTANA, RADY JUDITH, LUZARDO LORENZO, MARIA DEL CARMEN, ALONSO BIOSCA, MARIA EUGENIA, CRUZ LEAL, YOELYS
Format Patent
LanguageEnglish
French
German
Published 15.05.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoylphosphatidylcholine: cholesterol in a 1:1 molar ratio for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. The disclosed compositions allow modulation of CTL-specific immune response against one or several antigens co-encapsulated into toxin-containing liposomes. The vaccinal vehicle of the present invention shows advantages over others disclosed by the previous art due to the robustness and functionality of the induced immune response as well as its immunomodulating properties.
Bibliography:Application Number: EP20110743950