NOVEL AURISTATIN DERIVATIVES AND USE THEREOF

The present application relates to novel derivatives of monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and also to the use of these derivatives for preparing medicaments for treating and/or preventing dis...

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Bibliographic Details
Main Authors STELTE-LUDWIG, BEATRIX, GOLFIER, SVEN, KRENZ, URSULA, SCHUHMACHER, JOACHIM, LERCHEN, HANS-GEORG
Format Patent
LanguageEnglish
French
German
Published 17.04.2013
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present application relates to novel derivatives of monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and also to the use of these derivatives for preparing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as, for example, cancerous disorders. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
Bibliography:Application Number: EP20110725412