SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS

Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obes...

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Main Authors MONINGKA, REMOND, FINKE, PAUL, E, BAO, JIANMING, TYAGARAJAN, SRIRAM, PLOTKIN, MICHAEL, A, ONDEYKA, DEBRA, L, HUSSAIN, ZAHID, DUFFY, JOSEPH, L, ZANG, YI, ROMERO, F. ANTHONY, YE, FENG, SHAO, PATRICK, KATIPALLY, REVATHI
Format Patent
LanguageEnglish
French
German
Published 20.11.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obesity, atherosclerosis, Metabolic Syndrome, depression, and anxiety.
Bibliography:Application Number: EP20110783995