ISOTOPE PRODUCTION METHOD

The present invention relates to a method for the generation of 223 Ra of pharmaceutically tolerable purity comprising: i) preparing a generator mixture comprising 227 Ac, 227 Th and 223 Ra in a first aqueous solution comprising a first mineral acid; ii) loading said generator mixture onto a DGA sep...

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Bibliographic Details
Main Authors KARLSON, JAN ROGER, BOERRETZEN, PEER
Format Patent
LanguageEnglish
French
German
Published 19.03.2014
Subjects
CONVERSION OF CHEMICAL ELEMENTS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
NUCLEAR ENGINEERING
NUCLEAR PHYSICS
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
RADIOACTIVE SOURCES
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Summary:The present invention relates to a method for the generation of 223 Ra of pharmaceutically tolerable purity comprising: i) preparing a generator mixture comprising 227 Ac, 227 Th and 223 Ra in a first aqueous solution comprising a first mineral acid; ii) loading said generator mixture onto a DGA separation medium (e.g. resin); iii) eluting said 223 Ra from said DGA separation medium using a second mineral acid in a second aqueous solution to give an eluted 223 Ra solution; and iv) stripping the DGA separation medium of said 227 Ac and 227 Th by flowing a third mineral acid in a third aqueous solution through the DGA separation medium in a reversed direction; The invention further relates to high purity radium-223 formed or formable by such a method as well as pharmaceutical compositions comprising such radium-223 of pharmaceutical purity.
Bibliography:Application Number: EP20110719187