PROCESS FOR THE PRODUCTION OF POLYMORPH FORM I OF AGOMELATINE

The invention provides a process for the preparation of the polymorph from I of agomelatine, characterized by the following crystal data: C15H17N02 Mr = 243.30 Orthorhombic Pca21 a = 31.501 (4) Å b = 9.5280 (10) Å c = 17.906 (2) Å Z = 16 the process comprising the process steps of: a) dissolving ago...

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Bibliographic Details
Main Authors MATZDORF, THORSTEN, FISCHER, DIRK, NESS, WINFRIED
Format Patent
LanguageEnglish
French
German
Published 16.11.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a process for the preparation of the polymorph from I of agomelatine, characterized by the following crystal data: C15H17N02 Mr = 243.30 Orthorhombic Pca21 a = 31.501 (4) Å b = 9.5280 (10) Å c = 17.906 (2) Å Z = 16 the process comprising the process steps of: a) dissolving agomelatine in a solvent to obtain a solution, b) adding the solution to an organic anti-solvent having a temperature of 30°C or below, whereby crystals of the polymorph form I of agomelatine are formed, wherein the solvent of step a) is miscible with the anti-solvent of step b), c) isolating the crystals of the polymorph form I of agomelatine and d) optionally drying the isolated crystals of the polymorph form I of agomelatine.
Bibliography:Application Number: EP20110714311