DI-SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS

• Main Authors: OKUNO, MITSUHIRO, KOJIMA, YUTAKA, TAKASU, HIDEKI, MIYAJIMA, KEISUKE, YANAGIHARA, YASUO, YAMADA, SATOSHI, SAKAI, KOJI, OHTSUKA, SHINYA, FUJITA, SHIGEKAZU, SEKIGUCHI, KAZUO, SUGIYAMA, KAZUHISA, SATO, YOSUKE, HIROSE, TOSHIYUKI, SUZUKI, TAKASHI, SUMIDA, TAKUMI, TANAKA, HIDEO
• Format: Patent
• Language: English; French; German
• Published: 09.09.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is -NH-G2-, -N(lower alkyl)-G2-, -NH-CH2-G2-, -N(lower alkyl)-CH2-G2- or -CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O-R2, phenylene-G5-NH-R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O-R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is -O-lower alkylene-R2 or the like; G4-O- is lower alkylene-O- or the like; G5 is lower alkylene; G6 is lower alkylene].