PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE

The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of mak...

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Main Authors GALEMMO, ROBERT, A., JR, AUBELE, DANIELLE, L, ADLER, MARC, ARTIS, DEAN RICHARD, ZHU, YONG-LIANG, BEROZA, PAUL, HOM, ROY, K, YE, XIAOCONG MICHAEL, NEITZ, R., JEFFREY, BOWERS, SIMEON, SEALY, JENNIFER, ANDERSON, JOHN, P, TRUONG, ANH, P
Format Patent
LanguageEnglish
French
German
Published 21.01.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R1, R2, R3, R4, R5 and R6, are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.
Bibliography:Application Number: EP20100798439