STEREOSELECTIVE SYNTHESIS OF BETA-NUCLEOSIDES

A process of stereoselectively synthesizing ²-nucleoside of formula (I), e.g., 2'-deoxy-2,2'-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula: in which wherein R 1 , R 2 , R 3 , R 4 , and L as defined in the specification, wi...

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Bibliographic Details
Main Authors HWANG, CHAN-KOU, CHIEN, CHUNGSUN, CHIEN, PIN-SHU
Format Patent
LanguageEnglish
French
German
Published 25.02.2015
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:A process of stereoselectively synthesizing ²-nucleoside of formula (I), e.g., 2'-deoxy-2,2'-difluorocytidine, is described. The process includes reacting a tetrahydrofuran compound of the following formula: in which wherein R 1 , R 2 , R 3 , R 4 , and L as defined in the specification, with a nucleobase derivative in the presence of an oxidizing agent.
Bibliography:Application Number: EP20120163289