METHODS FOR AFFINITY MATURATION-BASED ANTIBODY OPTIMIZATION

Provided herein is a rational method of affinity maturation to evolve the activity of an antibody or portion thereof based on the structure/affinity or activity relationship of an antibody. The resulting affinity matured antibodies exhibit improved or optimized binding affinity for a target antigen.

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Bibliographic Details
Main Authors SMIDER, VAUGHN, MAO, HELEN, HONGYUAN
Format Patent
LanguageEnglish
French
German
Published 12.09.2012
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Provided herein is a rational method of affinity maturation to evolve the activity of an antibody or portion thereof based on the structure/affinity or activity relationship of an antibody. The resulting affinity matured antibodies exhibit improved or optimized binding affinity for a target antigen.
Bibliography:Application Number: EP20100774110