Indole derivatives as CRTH2 receptor antagonists in combination with a second active ingredient

Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma in combination with a second active ingredient such as a leukotriene antagonist.

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Bibliographic Details
Main Authors COLUCCI, JOHN, VILLENEUVE, KARINE, BOYD, MICHAEL, BERTHELETTE, CARL, METHOT, JOEY
Format Patent
LanguageEnglish
French
German
Published 29.08.2012
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma in combination with a second active ingredient such as a leukotriene antagonist.
Bibliography:Application Number: EP20120168410