METHOD FOR MEASUREMENT OF Mac-2-binding protein, METHOD FOR DETECTION OF HEPATIC DISEASES by measuring Mac-2-binding protein, REAGENT FOR QUANTIFICATION OF Mac-2-binding protein

• Main Authors: TANAKA YASUHITO, KUNO ATSUSHI, SOGABE MAKI, MATSUBARA SHUNSUKE, TSURUNO CHIKAYUKI, KAGAWA TAKASHI, NARIMATSU HISASHI, MIZOKAMI MASASHI, ITO KIYOAKI, NAGAI SHINYA, IKEHARA YUZURU, TAKAHAMA YOUICHI
• Format: Patent
• Language: English; French; German
• Published: 08.06.2016
• Subjects: CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; TESTING

An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a method for examining liver disease, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a reagent for quantitative determination of a glycoprotein, which is used for the above measurement methods. Furthermore, an object of the present invention is to provide a glycan-marker glycoprotein as an index for clinical conditions of liver disease, which is capable of identifying the clinical conditions of liver disease depending on the progress of liver disease. The method for measuring a glycoprotein is characterized in that: the glycoprotein is at least one glycoprotein selected from alpha-1-acid glycoprotein (AGP) and Mac-2-binding protein (M2BP) contained in a sample collected from a subject; when the glycoprotein is AGP, AGP binding to a first lectin selected from AOL and MAL is measured; and when the glycoprotein is M2BP, M2BP binding to a second lectin selected from WFA, BPL, AAL, RCA120, and TJAII is measured.