NOVEL THIOPHENE CARBOXAMIDE DERIVATIVE AND MEDICINAL USE OF SAME

• Main Authors: SAKAIRI, MASAO, CHIKAMATSU, KAORI, WATANABE, NOBUHIDE, MURAKAMI, SEI, KATO, NORIYASU, NAGAI, KAZUSHIGE, KASUGAI, NOBUYOSHI, HIRAMATSU, NAOKI, YAMADA, YURIE, KATAOKA, DAISUKE, FUJIEDA, HIROKI, YAMASHITA, TOKUYUKI, KATAOKA, HIROYO, MIYAZAWA, TOSHIYUKI, TAKAHASHI, NAOKI, KOGAMI, MASAKAZU, MAKINO, MITSUHIRO, TSURUTA, NOBUAKI, MIYOSHI, MIKA, IWAI, HISAKAZU
• Format: Patent
• Language: English; French; German
• Published: 09.01.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The object of the present invention is to provide a compound having a glucokinase-activating effect. A pharmaceutical composition comprising a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein X means a nitrogen atom or CR 6 wherein R 6 means a hydrogen atom or a halogen atom; R 1 means a hydrogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 alkylthio group; R 2 means a hydrogen atom or a fluorine atom; R 3 means a hydrogen atom or a C1-C6 alkyl group; and one of R 4 and R 5 means a hydrogen atom or a C1-C6 alkyl group, and the other means a C1-C6 alkylenecarboxylic acid, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, or CONH 2 .