HETEROARYL COMPOUNDS AS PIKK INHIBITORS

The present invention provides compounds that are PIKK inhibitors, more specifically, mTOR and/or PI3Kα kinase inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PI3 kinases, more specifically, mTOR and/or PI3Kα, such as cancer. Also pr...

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Bibliographic Details
Main Authors YI, SHUYAN, CHOQUETTE, DEBORAH, PETERSON, EMILY, A, GRACEFFA, RUSSELL, HUANG, HONGBING, LEWIS, RICHARD, BODE, CHRISTIANE, LA, DANIEL, STELLWAGEN, JOHN, STEC, MARKIAN, CHENG, ALAN, C, COATS, JAMES, R, BOEZIO, ALESSANDRO, NORMAN, MARK, COPELAND, KATRINA, W, POTASHMAN, MICHELE, LIAO, HONGYU
Format Patent
LanguageEnglish
French
German
Published 15.10.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds that are PIKK inhibitors, more specifically, mTOR and/or PI3Kα kinase inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of kinases, specifically PI3 kinases, more specifically, mTOR and/or PI3Kα, such as cancer. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
Bibliography:Application Number: EP20100719514